The negative modulation of TNF-α, IFN-γ, IL-10, IL-12p40, IL-17, may be associated with the reactivation of the infection observed in patients taking Infliximab or other TNF-α blockers, which increases the importance of screening for latent tuberculosis in patients with chronic inflammatory diseases candidates for the use of immunobiological TNF blockers. This evidence concerns the gene TNF and infection.