a form (hypo-reactivity cellular pole), although with high expression of CD8+T-cells (with twice the expression of CD4+T-cells), which reinforces the determinant role of the CD4+T-cell response in the definition of T-cell immune response profile against infection, whether of resistance (CD4+/Th1) or susceptibility (CD4+/Th2) to infection. Here, CD4 is linked to infection.