TGFB1 and autosomal dominant cutis laxa: That is, in general, the immune response profile found in most clinical forms of ACL (LCL, BDCL and ML)—with exception of ADCL, which is characterized by a strong CD4+/Th2-type immune response associated with low levels of CD8+ T-cells and high expression of IL-4, IL-10 and TGF-β cytokines.