Comparative analyses of cell densities expressing TNF-α+, TGF-β+, and IL-10+ in the different clinical forms of ACL caused by L. (V. ) braziliensis and L. (L. ) amazonensis showed greater (p< 0.05) expressions of TGF-β+ andIL-10+ cytokines in the clinical forms associated with L. (L. ) amazonensis (such as LCL, BDCL and ADCL), while TNF-α+ demonstrated greater (p< 0.05) expression in the clinical forms associated with L. (V. ) braziliensis(principallyLCL and ML) (Fig 2). This evidence concerns the gene TGFB1 and autosomal dominant cutis laxa.