In agreement with our results, a recent study in mouse models of diabetes showed decrease of plasma S1P levels in streptozotocin-induced diabetic mice.[42] Notably, S1P content of HDL has been associated with the presence of apoM.[43] However, we found that apoM levels were not different between T2D patients and controls suggesting that while apoM may control a large portion of HDL S1P content, it is not associated with decrease of S1P in diabetes and ultimately for HDL functionality. Here, APOM is linked to diabetes mellitus.