The CUR/DOX-h-PCEC@CRGDK NPs were demonstrated to be able to ratiometrically load DOX and CUR, allow for long circulation, enter the cells via CRGDK-receptor mediated tumor targeting, as well as realize tumor intracellular responsive and simultaneous corelease of DOX and CUR, thus effectively reversing the MDR through inhibiting P-gp expression. The gene discussed is PGP; the disease is neoplasm.