TRAF3IP2 and Granuloma: Further to this, αCT1 treatment of submuscular biomedical implants reduces type 1 collagen deposition and number of myofibroblasts around the implant [139], whilst αCT1 treatment of skin wounds leads to faster wound closure, reduced inflammation, swelling, neutrophil recruitment, and granulomas tissue, as well as improved mechanical properties of the skin following closure [140].