Also, COM has anti-cancerous effect against liver cancer (by regulation of caspase-3, p53, Bcl-2) [15], colorectal cancer (by modification of p53, p21, Bax and caspase-3) [16], and oral cancer (by modulation of PARP, Mcl-1) [17]. The gene discussed is BCL2; the disease is lip and oral cavity carcinoma.