To test this hypothesis, we screened supernatants from infected cell cultures 24 h post-HSV1716gfp infection (MOI 3) for candidate molecules including adenosine triphosphate (ATP), HMGB1, type 1 interferon (IFN-⍺, IFN-β), interleukin 1-β (IL-1β), and oncostatin M (Figure 3). This evidence concerns the gene HMGB1 and infection.