TLR2−/− and TLR4−/− mice produce similar levels of interleukin 1β (IL-1β), IL-6, IL-12p40 and tumor necrosis factor-α (TNF-α) compared to littermates during cryptococcal infection, and survival rates are similar compared to wild type (WT) mice [6,8]. The gene discussed is TNF; the disease is cryptococcosis.