In addition, these studies showed that the Ly-6Chi monocyte population differentiates into lung conventional DCs during cryptococcal infection, and in CCR2−/− mice, the Ly-6Chi DC precursor population accumulates in the bone marrow, suggesting that the reduced lung DC numbers are due to the lack of trafficking of DC precursor cells to the lung during cryptococcal infection [29]. The gene discussed is CCR2; the disease is cryptococcosis.