To further confirm the role of survivin in the sensitization, we tested effect of YM155 [21], a chemical inhibitor of survivin, on ABT-737-induced apoptosis in HepG2 cells and the results demonstrated that the inhibitor significantly sensitized the cancer cells to ABT-737-induced apoptosis (cleaved PARP) (Figure 3D), Together, these results clearly indicated that down-regulation of survivin contributed to the sensitization effect of GCM. Here, BIRC5 is linked to cancer.