For melanoma, the mutations of ubiquitination‐related genes such as BRCA1‐associated protein‐1(BAP1), F‐boxand WD repeat domain‐containing 7 (FBXW7) and PARK2 are frequently identified and participated in melanoma tumourigenesis.11 What is more, the activation of some critical signalling pathways in melanoma development including NF‐κB and MITF are also subtly regulated by ubiquitination,12, 13 demonstrating its vital pathogenic role in melanoma. The gene discussed is PRKN; the disease is melanoma.