As a result, cisplatin treatment was able to induce prominent cell apoptosis in melanoma, which was consistent with previous report.24 More importantly, although knockdown of USP4 expression alone had little impact on cell apoptosis, it could significantly sensitize melanoma cells to cisplatin‐induced cell death (Figure 3), suggesting that USP4 was a critical pro‐survival molecular in response to cisplatin treatment. Here, USP4 is linked to melanoma.