EDAR and neoplasm: In addition, the ectodysplasin receptor (EDAR), whose signalling pathway has been strongly implicated in enamel knot formation but not previously studied in ACP [55, 56], was highly expressed in ACP tumours compared with controls (467.88-fold; adjusted p value = 1.37E−29) and in β-catenin clusters relative to palisading epithelium (10.85-fold; adjusted p value = 0.0001) or glial reactive tissue (357.05-fold; adjusted p value = 9.77E−05) [Suppl.