CCL2 and neoplasm: Interestingly, we observed strong expression of the inflammasome-induced chemokine CCL2 in association with cholesterol clefts (Fig. 8a), while GSEA revealed a significant enrichment of an atherosclerotic plaque gene signature in ACP tumours relative to control tissues (NES = 2.12, FDR < 0.001) (Fig. 9b).