Interestingly, Hogervorst et al. (31, 32) showed significant interaction between AA intake and single-nucleotide polymorphisms (SNPs) in AA-metabolizing enzymes cytochrome P450, family 2, subfamily e, polypeptide 1 (CYP2E1) with endometrial cancer risk, and SNPs in the HSD3B1/B2 gene cluster (through effects on progesterone or androgens) with ovarian cancer risk. The gene discussed is CYP2E1; the disease is endometrial cancer.