In a KRAS-driven murine pancreatic ductal carcinoma (PDAC) model, loss of TGF-beta signaling leads to activation of GPCR-mediated JAK/STAT3 pathway signaling and stimulation of ROCK1, that increases tumor cell contractility, induces ECM remodeling and localized stiffening, and promotes focal adhesion maturation to promote tumor progression and aggression (Laklai et al., 2016). This evidence concerns the gene STAT3 and neoplasm.