In recent studies on site-directed mutagenesis in E-cad, the N558 (as Asn554), and N637 (as Asn633) were found aberrantly decorated with complex-type high-mannose N-glycans (β1,6 GlcNAc-branched), and critical for regulating the biological functions of E-cad in cancer (18, 34). Here, CDH1 is linked to cancer.