Vitamin D decreases the burden of major pathological aggregates in AD, including Aβ plaques and hyperphosphorylated tau protein (Durk, Han, & Chow, 2014; Yu et al., 2011) and augments activity of memantine in AD (Lemire, Brangier, Beaudenon, Duval, & Annweiler, 2016). This evidence concerns the gene MAPT and Alzheimer disease.