Several transcription factors like activating protein 2 (AP-2), androgen receptor (AR), c-Jun, c/EBP, c-Myb, CREB, GATA-2, heat shock factor (HSF1), interferon regulatory factor (IRF-1), p53, Sp3, STAT1, have been demonstrated to be SUMOylated in cancer [130-132]. This evidence concerns the gene TFAP2A and cancer.