Cancer-specific telomerase reverse transcriptase gene (TERT) promoter mutations (-146C>T and -124C>T) have been linked to reactivation of the epigenetically silenced TERT. TERT promoter mutations in human embryonic stem cells and their differentiation into fibroblasts and neural progenitor cells revealed that these mutations were capable of overcoming epigenetic silencing [16-20]. The gene discussed is TERT; the disease is cancer.