TP53 and neoplasm: In this manuscript, we found lncRNAs could regulate a series of critical tumor associated genes like P53, cyclinD1, β-catenin, E-cadherin and etc. involving in signaling networks like P53 pathway, cycle checkpointing group, Wnt/ β-catenin signal transduction cascades and EMT, ECM remodeling systems, which could modulate proliferation, survival and metastasis.