Furthermore, we found that lncRNAs regulated expression of key proteins within signal networks or biological processes (e.g., P53, Wnt/ β-catenin signaling, cell cycle checkpoints, epithelial mesenchymal transition (EMT), and extracellular matrix (ECM) remodeling), all of which regulate the malignant characteristics of cancer cells (Figure 4B). Here, TP53 is linked to cancer.