As mutp53 is an important determinant of HSF1 activity, HSF1 is specifically up-regulated by mutp53 but not wtp53 [11] and also controls the stability of mutp53 protein in human cancer cells via activation of Hsp90, which strongly stabilizes mutp53 [41], indicating cross-talk between HSF1 and mutp53. This evidence concerns the gene HSF1 and cancer.