Finally, both Mo-MDSCs and PMN-MDSCs differentiate into tumor-associated macrophages (TAMs) [11], which facilitate tumor cell growth and survival via secreting IL-6, EGF, and TNF [17, 18] and promote angiogenesis by VEGFA, Semaphorin 4D, and IL-8 [18–20]. This evidence concerns the gene IL6 and neoplasm.