The effect of mutations could relate to neighboring genes, such as the PTCH1 or FANCC gene or a processed transcript LINC00046, a protein coding gene DKFZP434H0512 or ERCC6L2. The PTCH1 gene is a well-known cancer gene involved in predisposition to basal cell carcinoma and other human tumors, but has also been implicated in CRC [28–30]. The gene discussed is ERCC6L2; the disease is colorectal carcinoma.