Sema4D+ve/high TAIs proved to be statistically negatively associated with Sema4D expression in tumor cells (p= 0.011), where Sema4D-ve/low expression in tumor cells correlated with increased infiltration of Sema4D+ve/high TAIs in the peri-tumoral stroma (Table 1). The gene discussed is SEMA4D; the disease is neoplasm.