Heat map of gene expression ranking indicated that these ECM associated genes were highly expressed in the colorectal cancer ECs (Figure 13A), especially with 4 genes ranked in the top 2000 genes out of over 44,000 detected microarray genes, i.e. ABI Family Member 3 Binding Protein (ABI3BP, No. 544), Coiled-Coil Domain Containing 80 (CCDC80, No.1378), SPON2 (No.1490) and THBS2 (No. 1883). Here, SPON2 is linked to colorectal cancer.