ESR1 and breast neoplasm: MetaCore disease biomarker analysis indicated that, among the first 20 disease annotations, three of the top five were breast neoplasm chemokines (p value = 2.04 × 10–4 and FDR = 6.52x10–3), breast neoplasm estrogen receptor 1 (ESR1, p value = 2.04 × 10–4 and FDR = 6.52 × 10–3) and breast neoplasm G-protein coupled receptor (GPCR) pathway regulation (p value = 1.32 × 10–3 and FDR = 2.25 × 10–2) (Figure 5).