SIRS patients were distinguished from sepsis patients at a DcR3 cutoff of 1.96 ng/ml (a value of 95% CI for SIRS tested) with a sensitivity of 90.77% and a specificity of 98.40%, better than the commonly used biomarkers of PCT, CRP, and IL-6 (Figure 1C). Here, CRP is linked to systemic inflammatory response syndrome.