NFKBIA and non-small cell lung carcinoma: Although our study did not adequately demonstrate whether TRIM71 interacted directly with IκB-α to promote its ubiquitination, and the role of phosphorylated AKT in IκB-α protein expression is still unclear, we did verify that the IκB-α/NF-κB pathway plays an important role in TRIM71-dependent proliferation of NSCLC cells.