Indeed, in accordance with our proteomic findings, we observed an interesting deregulation of the E3 ubiquitin ligases (TOPORS and XIAP), which together with the non-previously related to AD deregulation at protein level of LGALS3BP, Layilin, MICB, CD36 and DDIT3 constitute interesting proteins for further functional analysis to determine their role in AD. The gene discussed is TOPORS; the disease is Alzheimer disease.