DDIT3 and Alzheimer disease: Indeed, in accordance with our proteomic findings, we observed an interesting deregulation of the E3 ubiquitin ligases (TOPORS and XIAP), which together with the non-previously related to AD deregulation at protein level of LGALS3BP, Layilin, MICB, CD36 and DDIT3 constitute interesting proteins for further functional analysis to determine their role in AD.