One of the most interesting findings of the study consisted of the identification of the alteration of two E3 ubiquitin-protein ligases: XIAP and Topors, which has not been previously associated to AD, apart from the relevant association of 15 proteins and four of the six clusters of interacting proteins to the immune system, which highlight the important role of the inflammatory response in the AD pathogenesis [22, 23]. This evidence concerns the gene UBE2E3 and Alzheimer disease.