PRRT2 and Alzheimer disease: Our results related to the down-regulation of XIAP are in agreement with the observed downregulation of PKC in our dataset and in previous works related to AD [31, 69], where PKC stabilizes XIAP through phosphorylation to suppress apoptotic cell death [31] and its cross-talk with XIAP has been suggested to be crucial in regulating the impaired neuronal homeostasis [31].