Our findings provide validated novel altered proteins -LGALS3BP, Layilin, MICB, CD36, DDIT3, TOPORS and XIAP- non-previously associated to AD that should be further explored in subsequent studies to determine their usefulness as blood or CSF biomarkers and should be the focus of functional experiments to determine their role in AD to potentially identify new targets of AD intervention. The gene discussed is LGALS3BP; the disease is Alzheimer disease.