Although experimental data suggest that HCV may contribute to HCC by modulating pathways that promote malignant transformation of hepatocytes [61] and HCV core, NS3, and NS5A proteins were shown to be involved in a number of potentially oncogenic pathways in cell culture (resistance to apoptosis and ras oncogene-mediated transformation [62-65] no consensus has emerged yet. This evidence concerns the gene KRAS and hepatocellular carcinoma.