IFNL3 and Cirrhosis: Also, they found that IL28B serum levels had significant correlation with the different outcomes of HCV infection, especially among patients suffering from cirrhosis and HCC, where IL28 serum level tend to increase with the progression of the disease, but even if IL28B variants might play a significant role in HCV infection, they may not be considered as risk factors in the progression of the infection to advanced stages such as HCC.