The expressions of tumor necrosis factor (TNF)-α, IL-1β, IL-6, IL-17 and vascular endothelial growth factor (VEGF) were significantly reduced by berberine in the sera of rats with bovine type II collagen-induced arthritis, and the expression of VEGF and CD34 and the p-ERK, p-p38 and p-JNK activation were also inhibited [6]. The gene discussed is TNF; the disease is Arthritis.