About the potential relevance for the pathophysiology of migraine, the orexinergic axons are in nociceptive laminae of the medullary dorsal horn and in close apposition to thalamic trigeminovascular neurons, although no data are yet available regarding the direction in which orexin/hypocretin may modulate the thalamic trigeminovascular neurons. The gene discussed is HCRT; the disease is migraine disorder.