Dtxl-8P4 NPs greatly suppressed the expression of CD31 and MMP2, compared with other groups, verifying that tumor proliferation and metastasis were effectively restricted (Giatromanolaki et al., 1997; Bjorklund and Koivunen, 2005; Kim et al., 2009; Jacob and Prekeris, 2015). This evidence concerns the gene PECAM1 and neoplasm.