Importantly, chromatin immunoprecipitation-sequencing experiments (Winick-Ng et al., 2016) revealed interactions between 82-kDa ChAT, SATB1 and genes related to synapse function, as well as many genes previously identified in genome-wide association studies (GWAS) meta-analyses as candidate AD-risk genes, such as BIN1, CR1, EFNA5, MAGI2, MTHFD1L and PRUNE2 (Bertram, 2011). This evidence concerns the gene CHAT and Alzheimer disease.