For example, BACE1 anti-sense transcript (BACE1-AS) is upregulated along with BACE1 in AD model mice, human post-mortem tissue, and following exposure to Aβ in human embryonic kidney (HEK) cells (Faghihi et al., 2008; Modarresi et al., 2011). This evidence concerns the gene BACE1 and Alzheimer disease.