For example, primary neuron cultures prepared from brains of APP/PSEN1 double transgenic AD model mice that are transduced to transiently express 82-kDa ChAT have increased gene expression of golgi-associated, gamma-adaptin ear-containing, ARF binding protein 3 (GGA3), which encodes GGA3 (Albers et al., 2014). This evidence concerns the gene CHAT and Alzheimer disease.