GAB2 was another GWAS-identified risk gene identified in this study (Winick-Ng et al., 2016), which encodes GAB2 (GRB2-associated-binding protein 2) that interacts with many receptor tyrosine kinases and membrane proteins such as APP (reviewed in Pan et al., 2010), and has 10 SNPs associated with AD in apolipoprotein E (APOE) ε4 carriers (Reiman et al., 2007). This evidence concerns the gene APOE and Alzheimer disease.