CREBBP and Alzheimer disease: Interestingly, Zhang et al. (2009) showed that inhibiting SATB1 orthologs in C.  elegans reduces lifespan, and further show that changes in SATB1 expression levels and activation may also be related to AD pathology; knockdown of CREB-binding protein, a binding partner for SATB1, accelerates Aβ-induced paralysis in a transgenic C.  elegans AD model (Zhang et al., 2009).