BACE1 and Alzheimer disease: Knockdown of BACE1-AS in HEK cells or in AD model mice reduces BACE1 mRNA levels and Aβ production, suggesting that both BACE1 and BACE1-AS are necessary for amylodogenic cleavage of APP (Faghihi et al., 2008; Modarresi et al., 2011).