In detail, isolated anti-PM-Scl-75 have been more frequently found in patients with joint contractures and SSc, higher CK levels associate with anti-PM-Scl-100, whereas the simultaneous presence of anti-PM-Scl-75 and -100 are linked to muscle involvement, digital ulcers and ILD but lower prevalence of lung hypertension [125]. The gene discussed is EXOSC9; the disease is systemic sclerosis.