Importantly, we found that treatment with rhPAI-1 increase the phosphorylation of a group of signaling molecules, including ERK1/2 and AKT/mTOR in 116/FIP2 cells but not the negative control cells, suggesting that overexpression of Rab11-FIP2 increases sensitivity of CRC to PAI-1. This evidence concerns the gene SERPINE1 and colorectal carcinoma.