ADAM17 and chronic obstructive pulmonary disease: EGFR and ADAM17 are both involved in the broad spectrum of events that is characteristic of both CF and COPD lung disease, like excessive mucus expression [102–104], cytokine secretion [105], airway epithelial cell wound healing [106, 107], abnormal airway proliferation [108], maintenance of barrier integrity, and progressive lung tissue scarring [109].