BRD4 and cancer: From these 103 overlapping genes, we extracted BRD4 as a candidate target gene of miR-3140, because BRD4 has been shown to play a critical role in promoting tumor growth in several cancers through upregulates the transcription of oncogenes, including MYC and CCND2. Our gene expression array analysis showed that miR-3140 downregulated the expression of MYC and CCND2 as well as BRD4 in Panc1 cells, suggesting that BRD4 plays a critical role for tumor cell growth in Panc1 cells.