Interestingly, when data from studies 1 and 4, where 3 serial pre and post-treatment tumor biopsies were obtained from each patient, were pooled, progressive increase in tumor LMTK3 expression was noted with increasing number of chemotherapy cycles (mean LMTK3 expression 67.6 ± 74.9, 94.6 ± 96.0, 135.1 ± 108.1 for pre, post cycle 1, and post cycle 4-chemotherapy, P = 0.006 for post cycle 1 vs. baseline, P = 0.020 for post cycle 4 vs. baseline). This evidence concerns the gene LMTK3 and neoplasm.