MGMT and neoplasm: In univariate analysis the following parameters were significantly associated with survival: extent of resection (P < 0.001), postoperative KPS (<80/>/ = 80) (P = 0.027), KPS at tumor recurrence (P = 0.001), MGMT-methylation status (P = 0.013), adjuvant therapy after initial surgery (P = 0.003) and therapy for recurrent disease (P < 0.001).