FUNDC1 and ischemia: Our findings propose that FUNDC1-required mitophagy was activated by ischemia via p-FUNDC1Tyr18 downregulation but inhibited by reperfusion through upregulated CK2α and its substrate p-FUNDC1Ser13, redefining the paradigm of FUNDC1/mitophagy activation and inactivation during ischemia and reperfusion, respectively.