After laser irradiation, SGNP@PDA + DOX treatment triggered upregulation of MHC-II and CD40 among dendritic cells (DCs) in tumor-draining lymph nodes (Supplementary Figure 13) and elicited robust AH1-specific CD8+ T-cell responses in both primary and distal tumors (3.7-fold greater than DOX group in the primary tumor; and 2.0- and 1.8-fold greater than DOX group and SGNP@PDA group, respectively, in the contralateral tumor; Fig. 6a). Here, CD40 is linked to neoplasm.