CD8A and neoplasm: Here, we present, to the best of our knowledge, the first demonstration that a single round of PTT combined with a sub-therapeutic dose of DOX can markedly enhance elicitation of anti-tumor CD8+ T cells and NK cells, overcome immunosuppression in tumors, and exert systemic anti-tumor immunity that can effectively eliminate local as well as distant, untreated tumors in >85% of animals.