It is also plausible that WSB-1 could regulate the expression of only a selected number of HIF target genes, rather than all HIF-dependent expression, as it is the case in breast cancer, respectively, for co-factors p300 and DEK for GLUT-1 (SLC2A1) and VEGF (VEGFA) expression.28,29. The gene discussed is WSB1; the disease is breast cancer.