WSB1 and breast carcinoma: We have shown a novel role for WSB-1 in promotion of metastasis seeding and growth in breast cancer, suggesting that WSB-1 regulates key pathways for the establishment of secondary breast cancer in HR-negative patients, an area identified as of key importance in the field.30 Further clarification of the regulatory pathways downstream of WSB-1 will help to further elucidate the biology of these aggressive and invasive breast cancers, and potentially uncover novel potential therapeutic targets.