Thus, we addressed how ES-62 might impact on IL-33/ST2 signalling in asthma by investigating its effects in a chronic OVA/alum model of asthma in WT and ST2 KO BALB/c mice55: whilst the majority (4/6) of the WT mice with OVA-induced pathology died before the end of the protocol, all such mice (6/6) treated with ES-62 survived. This evidence concerns the gene IL1RL1 and asthma.