Several genes have been identified to be associated with POAG, primary congenital glaucoma (PCG) and JOAG, including myocilin (MYOC)6; optineurin (OPTN)7; WD repeat domain 36 (WDR36)8; neurotrophin 4 (NTF4)9; and cytochrome P450 family 1, subfamily B(CYP1B1)10. The gene discussed is OPTN; the disease is open-angle glaucoma.