Since the RSK2 signaling pathway induces the transactivation activities of AP-1, and NF-κB regulates cell proliferation, cell migration, and inflammation19, 39 by regulation of activated T-cell 3 (NFAT3) nuclear factors and RSK2/NFAT3-mediated IL-2 promoter activity39, these results suggest that RSK2 plays a critical role in T-cell activation in vitro and in vivo40, and provide us with an opportunity to establish the hypothesis that RSK2 might be involved in RA development. This evidence concerns the gene NFATC4 and rheumatoid arthritis.