The results indicated that the bFGF concentrations in the SF of RA patients with severe joint damage (70–73 pg/ml) were 5.5- and 20.6-fold higher than that in the SF of RA patients with less joint damage (8.4–18.9 pg/ml) and OA patients (3.6 pg/ml), respectively6. The gene discussed is FGF2; the disease is rheumatoid arthritis.