LAMB2 and Familial prostate cancer: Given that the axis laminin-111/integrin-α6β1 has been associated with long-term self-renewal of induced-pluripotent stem cells49,50, with sphere-forming capacity of human prostate cancer stem cells and neural stem cells51,52, and with asymmetric cell division of Drosophila ovarian follicle stem cells53, it is likely that interaction between laminins and integrins represents an ancient mechanism to maintain stem cell self-renewal.