For example, the 11.1-kb [S100A3-S100A4circle 153,512-153,523kb] in sample T8 included the complete genes of S100A3 and S100A4 and parts of S100A5. S100A4 encodes a protein known to have a causal role in the metastatic spread of tumor cells35. Here, S100A3 is linked to neoplasm.