FOXO3 and breast carcinoma: Appropriately, FOXK2 has previously been reported to mediate the cytotoxic function of paclitaxel through regulating the expression of the FOXO3 transcription factor in breast cancer cells9, while FOXO3, in turn, is essential for mediating the effects of paclitaxel in breast cancer cells through driving the expression of downstream apoptotic target genes, such as Bim17,18.