We next performed this set of experiments with the K527/633 R mutant FOXK2 in the triple negative MDA-MB-231 breast carcinoma cells and again found the K527/633 R mutant form of FOXK2 is defective in conferring the cytotoxic/cytostatic functions of paclitaxel in MDA-MB-231 cells (Figs. 3a, b). This evidence concerns the gene FOXK2 and breast carcinoma.