HDAC3 and hepatocellular carcinoma: We performed immunohistochemistry to assess HDAC3 expression in tissues from 90 HCC cases, and observed that 27 cases exhibited strong nuclear and cytoplasmic HDAC3 positivity, and that HDAC3 was either negatively or weakly expressed in the corresponding adjacent non-tumor tissues (Fig. 6a; Supplementary Table 4).