Genes ranked from the second to tenth are as follows: CACNA1C, CACNB2, GRIN2A, CNKSR2, SERPING1, ZNF536, GPM6A, VRK2, and GRIA1. Dysregulation of the dopamine system in the pathophysiology of schizophrenia has been well characterized. This evidence concerns the gene CACNA1C and schizophrenia.