Soluble HLA-G (sHLA-G) has been detected in both the maternal serum/plasma and amniotic fluid, and its concentrations are influenced by the gestational age and several maternal or fetal complications, including fetal gender, fetal neural tube defect, intraamniotic inflammations/infections, and preeclampsia [7, 9, 22–24]. Here, HLA-G is linked to preeclampsia.