Imposing a stronger significance threshold of P = 0.00625 (0.05/8, to correct for testing four traits over two outcomes), no histology-specific associations were shown by the IVW method between asthma and hay fever, IgE levels and self-reported allergy and glioma risk, with the respective ORs for the IVW method being 0.97, 0.92 and 1.04 for GBM tumours, and 0.96, 0.97 and 1.04 for non-GBM tumours (Additional file 7: Table S6). Here, IGHE is linked to allergic disease.