IGHE and central nervous system cancer: Epidemiological observational studies have reported inverse relationships between atopy-related traits and glioma risk, with ORs in the range 0.43–0.96 for asthma [6, 47], 0.42–0.90 for atopic dermatitis [6, 47], 0.37–0.73 for IgE levels [8–10] and 0.47–0.69 for self-reported allergies [4, 5, 8].