Using MLE, no associations were identified between asthma and hay fever (OR 0.96, 95% CI 0.93–1.00, P = 0.066), IgE levels (OR 0.88, 95% CI 0.74–1.05, P = 0.157) or self-reported allergy (OR 1.02, 95% CI 0.97–1.08, P = 0.429) with risk of all glioma. The gene discussed is IGHE; the disease is central nervous system cancer.