Using the IVW method to pool results from individual SNPs, no associations (i.e. P ≥ 0.05) were identified between genetically conferred risk of raised IgE level (OR 0.88, 95% CI 0.69–1.13, P = 0.319), asthma and hay fever (OR 0.96, 95% CI 0.90–1.03, P = 0.248), or self-reported allergy (OR 1.03, 95% CI 0.95–1.11, P = 0.534) with risk of all glioma. The gene discussed is IGHE; the disease is central nervous system cancer.