There was minimal evidence of heterogeneity between variants for asthma and hay fever, atopic dermatitis, IgE levels and self-reported allergy (respective I2 and Phet values being 28% and 0.192, 8% and 0.377, 0% and 0.444, and 0% and 0.707). The gene discussed is IGHE; the disease is seasonal allergic rhinitis.